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Retatrutide (GIP/GLP-1/glucagon) triple agonist research peptide

Retatrutide is an investigational synthetic peptide studied as a single molecule that activates three receptors: GIP, GLP-1 and glucagon. Snowman carries retatrutide powder in seven vial sizes, from 5mg to 60mg, each sealed as a lyophilized cake. Research use only; it is not an approved medicine and is never for human use. Seen it called Reta, GLP-3 or triple G? The Sema, Tirz and Reta name decoder explains each nickname.

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The glucagon receptor, briefly

Retatrutide (development code LY3437943) is one peptide that activates three receptors: those for GIP, GLP-1 and glucagon. Researchers call this a triple hormone-receptor agonist, which also makes retatrutide a glucagon receptor agonist in addition to its GIP and GLP-1 activity[1]. Compare it with tirzepatide, a dual agonist of the GIP and GLP-1 receptors only, on the tirzepatide family page.

  1. Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. 2023;389(6):514-526. PMID 37366315. https://pubmed.ncbi.nlm.nih.gov/37366315/